Simian Immunodeficiency Virus Promoter Exchange Results in a Highly Attenuated Strain That Protects against Uncloned Challenge Virus

Among the many simian immunodeficiency virus (SIV) immunogens, only live attenuated viral vaccines have afforded strong protection to a natural pathogenic isolate. Since the promoter is crucial to the tempo of viral replication in general, it was reasoned that promoter exchange might confer a novel...

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Detalhes bibliográficos
Main Authors: Blancou, Philippe, Chenciner, Nicole, Fang, Raphaël Ho Tsong, Monceaux, Valérie, Cumont, Marie-Christine, Guétard, Denise, Hurtrel, Bruno, Wain-Hobson, Simon
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC321388/
https://ncbi.nlm.nih.gov/pubmed/14722263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.3.1080-1092.2004
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