Accounting for genetic heterogeneity in homozygosity mapping: Application to Mendelian susceptibility to mycobacterial disease

Genome-wide (GW) homozygosity mapping (HM) is a powerful method to locate rare recessive Mendelian mutations. However, statistical power decreases dramatically in the presence of genetic heterogeneity. We applied an empirical approach to test for linkage accounting for genetic heterogeneity by calcu...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Grant, Audrey V., Boisson-Dupuis, Stéphanie, Herquelot, Eléonore, de Beaucoudrey, Ludovic, Filipe-Santos, Orchidée, Nolan, Daniel K., Feinberg, Jacqueline, Boland, Anne, Sanal, Ozden, Camcioglu, Yildiz, Palanduz, Ayse, Kilic, Sara Sebnem, Bustamante, Jacinta, Casanova, Jean-Laurent, Abel, Laurent
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2011
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3213022/
https://ncbi.nlm.nih.gov/pubmed/21572128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jmg.2011.089128
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