Accounting for genetic heterogeneity in homozygosity mapping: Application to Mendelian susceptibility to mycobacterial disease

Genome-wide (GW) homozygosity mapping (HM) is a powerful method to locate rare recessive Mendelian mutations. However, statistical power decreases dramatically in the presence of genetic heterogeneity. We applied an empirical approach to test for linkage accounting for genetic heterogeneity by calcu...

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Main Authors: Grant, Audrey V., Boisson-Dupuis, Stéphanie, Herquelot, Eléonore, de Beaucoudrey, Ludovic, Filipe-Santos, Orchidée, Nolan, Daniel K., Feinberg, Jacqueline, Boland, Anne, Sanal, Ozden, Camcioglu, Yildiz, Palanduz, Ayse, Kilic, Sara Sebnem, Bustamante, Jacinta, Casanova, Jean-Laurent, Abel, Laurent
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3213022/
https://ncbi.nlm.nih.gov/pubmed/21572128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jmg.2011.089128
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