Accounting for genetic heterogeneity in homozygosity mapping: Application to Mendelian susceptibility to mycobacterial disease

Genome-wide (GW) homozygosity mapping (HM) is a powerful method to locate rare recessive Mendelian mutations. However, statistical power decreases dramatically in the presence of genetic heterogeneity. We applied an empirical approach to test for linkage accounting for genetic heterogeneity by calcu...

詳細記述

保存先:
書誌詳細
主要な著者: Grant, Audrey V., Boisson-Dupuis, Stéphanie, Herquelot, Eléonore, de Beaucoudrey, Ludovic, Filipe-Santos, Orchidée, Nolan, Daniel K., Feinberg, Jacqueline, Boland, Anne, Sanal, Ozden, Camcioglu, Yildiz, Palanduz, Ayse, Kilic, Sara Sebnem, Bustamante, Jacinta, Casanova, Jean-Laurent, Abel, Laurent
フォーマット: Artigo
言語:Inglês
出版事項: 2011
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3213022/
https://ncbi.nlm.nih.gov/pubmed/21572128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jmg.2011.089128
タグ: タグ追加
タグなし, このレコードへの初めてのタグを付けませんか!

類似資料