KINETICS OF O(6)-Me-dG REPAIR BY O(6)-ALKYLGUANINE DNA ALKYLTRANSFERASE WITHIN K-RAS GENE DERIVED DNA SEQUENCES

O(6)-methyl-2'-deoxyguanosine (O(6)-Me-dG) is a potent mutagenic DNA adduct that can be induced by a variety of methylating agents, including tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). O(6)-Me-dG is directly repaired by the specialized DNA repair protein...

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Bibliografski detalji
Glavni autori: Guza, Rebecca, Rajesh, Mathur, Fang, Qingming, Pegg, Anthony E., Tretyakova, Natalia
Format: Artigo
Jezik:Inglês
Izdano: 2006
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3213021/
https://ncbi.nlm.nih.gov/pubmed/16608164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx050348d
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