Cell type and gender-dependent differential regulation of the p202 and Aim2 proteins: implications for the regulation of innate immune responses in SLE

Upon sensing cytosolic double-stranded DNA (dsDNA), the murine Aim2 (encoded by the Aim2 gene) protein forms an inflammasome and promotes the secretion of proinflammatory cytokines, such as IL-1β and IL-18. In contrast, the p202 protein (encoded by the Ifi202 gene) does not form an inflammasome. Pre...

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Hoofdauteurs: Panchanathan, Ravichandran, Duan, Xin, Arumugam, Muthuvel, Shen, Hui, Liu, Hongzhu, Choubey, Divaker
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2011
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3211081/
https://ncbi.nlm.nih.gov/pubmed/21943709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2011.08.022
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