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Hypoxia primes human normal prostate epithelial cells and cancer cell lines for the NLRP3 and AIM2 inflammasome activation

The molecular mechanisms by which hypoxia contributes to prostatic chronic inflammation (PCI) remain largely unknown. Because hypoxia stimulates the transcriptional activity of NF-κB, which “primes” cells for inflammasome activation by inducing the expression of NLRP3 or AIM2 receptor and pro-IL-1β,...

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Podrobná bibliografie
Vydáno v:Oncotarget
Hlavní autoři: Panchanathan, Ravichandran, Liu, Hongzhu, Choubey, Divaker
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5053719/
https://ncbi.nlm.nih.gov/pubmed/27058421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8594
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