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Crystallographic snapshots of the complete catalytic cycle of the unregulated aspartate transcarbamoylase from Bacillus subtilis

Here we report high-resolution X-ray structures of Bacillus subtilis aspartate transcarbamoylase (ATCase), an enzyme that catalyzes one of the first reactions in pyrimidine nucleotide biosynthesis. Structures of the enzyme have been determined in the absence of ligands, in the presence of the substr...

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Hlavní autoři: Harris, Katharine M., Cockrell, Gregory M., Puleo, David E., Kantrowitz, Evan R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3211067/
https://ncbi.nlm.nih.gov/pubmed/21663747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.05.036
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