Occupancy of dopamine D(2) and D(3) and serotonin 5-HT(1A) receptors by the novel antipsychotic drug candidate, cariprazine (RGH-188), in monkey brain measured using positron emission tomography

RATIONALE: Cariprazine is a novel antipsychotic drug candidate that exhibits high selectivity and affinity to dopamine D(3) and D(2) receptors and moderate affinity to serotonin 5-HT(1A) receptors. Targeting receptors other than D(2) may provide a therapeutic benefit for both positive and negative s...

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Detalhes bibliográficos
Main Authors: Seneca, Nicholas, Finnema, Sjoerd J., Laszlovszky, István, Kiss, Béla, Horváth, Attila, Pásztor, Gabriella, Kapás, Margó, Gyertyán, István, Farkas, Sándor, Innis, Robert B., Halldin, Christer, Gulyás, Balás
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3210913/
https://ncbi.nlm.nih.gov/pubmed/21625907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-011-2343-z
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