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Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status
AIM/HYPOTHESIS: The glucose-lowering drug metformin has been shown to activate hepatic AMP-activated protein kinase (AMPK), a master kinase regulating cellular energy homeostasis. However, the underlying mechanisms remain controversial and have never been investigated in primary human hepatocytes. M...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer-Verlag
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3210354/ https://ncbi.nlm.nih.gov/pubmed/21947382 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-011-2311-5 |
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