In Embryonic Stem Cells, ZFP57/KAP1 Recognize a Methylated Hexanucleotide to Affect Chromatin and DNA Methylation of Imprinting Control Regions

The maintenance of H3K9 and DNA methylation at imprinting control regions (ICRs) during early embryogenesis is key to the regulation of imprinted genes. Here, we reveal that ZFP57, its cofactor KAP1, and associated effectors bind selectively to the H3K9me3-bearing, DNA-methylated allele of ICRs in E...

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Main Authors: Quenneville, Simon, Verde, Gaetano, Corsinotti, Andrea, Kapopoulou, Adamandia, Jakobsson, Johan, Offner, Sandra, Baglivo, Ilaria, Pedone, Paolo V., Grimaldi, Giovanna, Riccio, Andrea, Trono, Didier
格式: Artigo
語言:Inglês
出版: Cell Press 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3210328/
https://ncbi.nlm.nih.gov/pubmed/22055183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.08.032
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