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Flexible catalytic site conformations implicated in modulation of HIV-1 protease autoprocessing reactions

BACKGROUND: The HIV-1 protease is initially synthesized as part of the Gag-Pol polyprotein in the infected cell. Protease autoprocessing, by which the protease domain embedded in the precursor catalyzes essential cleavage reactions, leads to liberation of the free mature protease at the late stage o...

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Detalhes bibliográficos
Main Authors: Huang, Liangqun, Li, Yanfei, Chen, Chaoping
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3210109/
https://ncbi.nlm.nih.gov/pubmed/21985091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-8-79
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