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Mitochondrial respiratory complex I dysfunction promotes tumorigenesis through ROS alteration and AKT activation
Previously, we have shown that a heteroplasmic mutation in mitochondrial DNA-encoded complex I ND5 subunit gene resulted in an enhanced tumorigenesis through increased resistance to apoptosis. Here we report that the tumorigenic phenotype associated with complex I dysfunction could be reversed by in...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3209831/ https://ncbi.nlm.nih.gov/pubmed/21890492 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddr395 |
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