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A heteroplasmic, not homoplasmic, mitochondrial DNA mutation promotes tumorigenesis via alteration in reactive oxygen species generation and apoptosis

Mitochondrial alteration has been long proposed to play a major role in tumorigenesis. Recently, mitochondrial DNA (mtDNA) mutations have been found in a variety of cancer cells. In this study, we examined the contribution of mtDNA mutation and mitochondrial dysfunction in tumorigenesis first using...

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Bibliografiske detaljer
Main Authors: Park, Jeong Soon, Sharma, Lokendra Kumar, Li, Hongzhi, Xiang, Ruihua, Holstein, Deborah, Wu, Jun, Lechleiter, James, Naylor, Susan L., Deng, Janice J., Lu, Jianxin, Bai, Yidong
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2733816/
https://ncbi.nlm.nih.gov/pubmed/19208652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddp069
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