Calcium microdomains at the immunological synapse: how ORAI channels, mitochondria and calcium pumps generate local calcium signals for efficient T-cell activation

Cell polarization enables restriction of signalling into microdomains. Polarization of lymphocytes following formation of a mature immunological synapse (IS) is essential for calcium-dependent T-cell activation. Here, we analyse calcium microdomains at the IS with total internal reflection fluoresce...

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Detalhes bibliográficos
Main Authors: Quintana, Ariel, Pasche, Mathias, Junker, Christian, Al-Ansary, Dalia, Rieger, Heiko, Kummerow, Carsten, Nuñez, Lucia, Villalobos, Carlos, Meraner, Paul, Becherer, Ute, Rettig, Jens, Niemeyer, Barbara A, Hoth, Markus
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3209779/
https://ncbi.nlm.nih.gov/pubmed/21847095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.289
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