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Nucleophosmin deposition during mRNA 3′ end processing influences poly(A) tail length

During polyadenylation, the multi-functional protein nucleophosmin (NPM1) is deposited onto all cellular mRNAs analysed to date. Premature termination of poly(A) tail synthesis in the presence of cordycepin abrogates deposition of the protein onto the mRNA, indicating natural termination of poly(A)...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Sagawa, Fumihiko, Ibrahim, Hend, Morrison, Angela L, Wilusz, Carol J, Wilusz, Jeffrey
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3209774/
https://ncbi.nlm.nih.gov/pubmed/21822216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.272
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