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Nucleophosmin deposition during mRNA 3′ end processing influences poly(A) tail length

During polyadenylation, the multi-functional protein nucleophosmin (NPM1) is deposited onto all cellular mRNAs analysed to date. Premature termination of poly(A) tail synthesis in the presence of cordycepin abrogates deposition of the protein onto the mRNA, indicating natural termination of poly(A)...

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Detalhes bibliográficos
Main Authors: Sagawa, Fumihiko, Ibrahim, Hend, Morrison, Angela L, Wilusz, Carol J, Wilusz, Jeffrey
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3209774/
https://ncbi.nlm.nih.gov/pubmed/21822216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.272
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