The feelgood mutation in zebrafish dysregulates COPII-dependent secretion of select extracellular matrix proteins in skeletal morphogenesis

Craniofacial and skeletal dysmorphologies account for the majority of birth defects. A number of the disease phenotypes have been attributed to abnormal synthesis, maintenance and composition of extracellular matrix (ECM), yet the molecular and cellular mechanisms causing these ECM defects remain po...

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Main Authors: Melville, David B., Montero-Balaguer, Mercedes, Levic, Daniel S., Bradley, Kevin, Smith, Jeffrey R., Hatzopoulos, Antonis K., Knapik, Ela W.
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists Limited 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3209646/
https://ncbi.nlm.nih.gov/pubmed/21729877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.007625
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