Evolution and Protein Packaging of Small Molecule RNA Aptamers

A high-affinity RNA aptamer (K(d) = 50 nM) was efficiently identified by SELEX against a heteroaryl dihydropyrimidine structure, chosen as a representative drug-like molecule with no cross reactivity with mammalian or bacterial cells. This aptamer, its weaker-binding variants, and a known aptamer ag...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Lau, Jolene L., Baksh, Michael M., Fiedler, Jason D., Brown, Steven D., Kussrow, Amanda, Bornhop, Darryl J., Ordoukhanian, Phillip, Finn, M.G.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2011
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3209476/
https://ncbi.nlm.nih.gov/pubmed/21899290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/nn2006927
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