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Evolution and Protein Packaging of Small Molecule RNA Aptamers
A high-affinity RNA aptamer (K(d) = 50 nM) was efficiently identified by SELEX against a heteroaryl dihydropyrimidine structure, chosen as a representative drug-like molecule with no cross reactivity with mammalian or bacterial cells. This aptamer, its weaker-binding variants, and a known aptamer ag...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3209476/ https://ncbi.nlm.nih.gov/pubmed/21899290 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/nn2006927 |
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