Analysis of Influenza Virus Hemagglutinin Receptor Binding Mutants with Limited Receptor Recognition Properties and Conditional Replication Characteristics

To examine the range of selective processes that potentially operate when poorly binding influenza viruses adapt to replicate more efficiently in alternative environments, we passaged a virus containing an attenuating mutation in the hemagglutinin (HA) receptor binding site in mice and characterized...

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Detalhes bibliográficos
Main Authors: Bradley, Konrad C., Galloway, Summer E., Lasanajak, Yi, Song, Xuezheng, Heimburg-Molinaro, Jamie, Yu, Hai, Chen, Xi, Talekar, Ganesh R., Smith, David F., Cummings, Richard D., Steinhauer, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3209400/
https://ncbi.nlm.nih.gov/pubmed/21917953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05570-11
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