Three-Dimensional Structures of Soluble CD4-Bound States of Trimeric Simian Immunodeficiency Virus Envelope Glycoproteins Determined by Using Cryo-Electron Tomography

The trimeric envelope glycoprotein (Env) spikes displayed on the surfaces of simian immunodeficiency virus (SIV) and human immunodeficiency virus type 1 (HIV-1) virions are composed of three heterodimers of the viral glycoproteins gp120 and gp41. Although binding of gp120 to cell surface CD4 and a c...

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Bibliographic Details
Main Authors: White, Tommi A., Bartesaghi, Alberto, Borgnia, Mario J., de la Cruz, M. Jason V., Nandwani, Rachna, Hoxie, James A., Bess, Julian W., Lifson, Jeffrey D., Milne, Jacqueline L. S., Subramaniam, Sriram
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2011
Subjects:
Structure and Assembly
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3209358/
https://ncbi.nlm.nih.gov/pubmed/21937655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05297-11
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