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Mutations in the Membrane-Proximal Region of the Influenza A Virus M2 Protein Cytoplasmic Tail Have Modest Effects on Virus Replication

Influenza A virus encodes M2, a proton channel that has been shown to be important during virus entry and assembly. In order to systematically investigate the role of the membrane-proximal residues in the M2 cytoplasmic tail in virus replication, we utilized scanning and directed alanine mutagenesis...

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Главные авторы: Stewart, Shaun M., Pekosz, Andrew
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2011
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3209349/
https://ncbi.nlm.nih.gov/pubmed/21917980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05970-11
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