Map2k4 Functions as a Tumor Suppressor in Lung Adenocarcinoma and Inhibits Tumor Cell Invasion by Decreasing Peroxisome Proliferator-Activated Receptor γ2 Expression

MAP2K4 encodes a dual-specificity kinase (mitogen-activated protein kinase kinase 4, or MKK4) that is mutated in a variety of human malignancies, but the biochemical properties of the mutant kinases and their roles in tumorigenesis have not been fully elucidated. Here we showed that 8 out of 11 canc...

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Detalhes bibliográficos
Main Authors: Ahn, Young-Ho, Yang, Yanan, Gibbons, Don L., Creighton, Chad J., Yang, Fei, Wistuba, Ignacio I., Lin, Wei, Thilaganathan, Nishan, Alvarez, Cristina A., Roybal, Jonathon, Goldsmith, Elizabeth J., Tournier, Cathy, Kurie, Jonathan M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3209326/
https://ncbi.nlm.nih.gov/pubmed/21896780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.05562-11
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