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Role of the Two Sialic Acid Binding Sites on the Newcastle Disease Virus HN Protein in Triggering the Interaction with the F Protein Required for the Promotion of Fusion

Newcastle disease virus (NDV)-induced membrane fusion requires an interaction between the hemagglutinin-neuraminidase (HN) attachment and the fusion (F) proteins, triggered by HN′s binding to receptors. NDV HN has two sialic acid binding sites: site I, which also mediates neuraminidase activity, and...

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Detalhes bibliográficos
Main Authors: Mahon, Paul J., Mirza, Anne M., Iorio, Ronald M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3209324/
https://ncbi.nlm.nih.gov/pubmed/21880745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05679-11
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