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A Mutation in the Stalk of the Newcastle Disease Virus Hemagglutinin-Neuraminidase (HN) Protein Prevents Triggering of the F Protein despite Allowing Efficient HN-F Complex Formation

Newcastle disease virus (NDV)-induced membrane fusion requires formation of a complex between the hemagglutinin-neuraminidase (HN) and fusion (F) proteins. Substitutions for NDV HN stalk residues A89, L90, and L94 block fusion by modulating formation of the HN-F complex. Here, we demonstrate that a...

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Библиографические подробности
Главные авторы: Mirza, Anne M., Iorio, Ronald M.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2013
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3719806/
https://ncbi.nlm.nih.gov/pubmed/23740987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01066-13
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