Compensatory Mutations Restore the Replication Defects Caused by Cytotoxic T Lymphocyte Escape Mutations in Hepatitis C Virus Polymerase

While human leukocyte antigen B57 (HLA-B57) is associated with the spontaneous clearance of hepatitis C virus (HCV), the mechanisms behind this control remain unclear. Immunodominant CD8(+) T cell responses against the B57-restricted epitopes comprised of residues 2629 to 2637 of nonstructural prote...

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Main Authors: Oniangue-Ndza, Cesar, Kuntzen, Thomas, Kemper, Michael, Berical, Andrew, Wang, Yaoyu E., Neumann-Haefelin, Christoph, Foote, Peter Kristian, Hills-Evans, Kelsey, Reyor, Laura L., Kane, Katherine, Gladden, Adrianne D., Bloom, Allyson K., Power, Karen A., Thimme, Robert, Lauer, Georg M., Henn, Matthew R., Kim, Arthur Y., Allen, Todd M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2011
Fag:
Pathogenesis and Immunity
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3209273/
https://ncbi.nlm.nih.gov/pubmed/21880756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00779-11
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