The Fbx4 Tumor Suppressor Regulates Cyclin D1 Accumulation and Prevents Neoplastic Transformation

Skp1-Cul1-F-box (SCF) E3 ubiquitin ligase complexes modulate the accumulation of key cell cycle regulatory proteins. Following the G(1)/S transition, SCF(Fbx4) targets cyclin D1 for proteasomal degradation, a critical event necessary for DNA replication fidelity. Deregulated cyclin D1 drives tumorig...

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Autors principals: Vaites, Laura Pontano, Lee, Eric K., Lian, Zhaorui, Barbash, Olena, Roy, Darshan, Wasik, Mariusz, Klein-Szanto, Andres J. P., Rustgi, Anil K., Diehl, J. Alan
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2011
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3209253/
https://ncbi.nlm.nih.gov/pubmed/21911473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.05733-11
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