Gata-3 Negatively Regulates the Tumor-Initiating Capacity of Mammary Luminal Progenitor Cells and Targets the Putative Tumor Suppressor Caspase-14

The transcription factor Gata-3 is a definitive marker of luminal breast cancers and a key regulator of mammary morphogenesis. Here we have explored a role for Gata-3 in tumor initiation and the underlying cellular mechanisms using a mouse model of “luminal-like” cancer. Loss of a single Gata-3 alle...

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Hoofdauteurs: Asselin-Labat, Marie-Liesse, Sutherland, Kate D., Vaillant, François, Gyorki, David E., Wu, Di, Holroyd, Sheridan, Breslin, Kelsey, Ward, Teresa, Shi, Wei, Bath, Mary L., Deb, Siddhartha, Fox, Stephen B., Smyth, Gordon K., Lindeman, Geoffrey J., Visvader, Jane E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2011
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Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3209243/
https://ncbi.nlm.nih.gov/pubmed/21930782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.05766-11
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