Gata-3 Negatively Regulates the Tumor-Initiating Capacity of Mammary Luminal Progenitor Cells and Targets the Putative Tumor Suppressor Caspase-14

The transcription factor Gata-3 is a definitive marker of luminal breast cancers and a key regulator of mammary morphogenesis. Here we have explored a role for Gata-3 in tumor initiation and the underlying cellular mechanisms using a mouse model of “luminal-like” cancer. Loss of a single Gata-3 alle...

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Autors principals: Asselin-Labat, Marie-Liesse, Sutherland, Kate D., Vaillant, François, Gyorki, David E., Wu, Di, Holroyd, Sheridan, Breslin, Kelsey, Ward, Teresa, Shi, Wei, Bath, Mary L., Deb, Siddhartha, Fox, Stephen B., Smyth, Gordon K., Lindeman, Geoffrey J., Visvader, Jane E.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2011
Matèries:
Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3209243/
https://ncbi.nlm.nih.gov/pubmed/21930782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.05766-11
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