Toward Improvement of Erythromycin A Production in an Industrial Saccharopolyspora erythraea Strain via Facilitation of Genetic Manipulation with an Artificial attB Site for Specific Recombination

Large-scale production of erythromycin A (Er-A) relies on the organism Saccharopolyspora erythraea, in which lack of a typical attB site largely impedes the application of phage ΦC31 integrase-mediated recombination into site-specific engineering. We herein report construction of an artificial attB...

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Autores principales: Wu, Jiequn, Zhang, Qinglin, Deng, Wei, Qian, Jiangchao, Zhang, Siliang, Liu, Wen
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2011
Materias:
Biotechnology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3209160/
https://ncbi.nlm.nih.gov/pubmed/21841022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.06034-11
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