Nostophycin Biosynthesis Is Directed by a Hybrid Polyketide Synthase-Nonribosomal Peptide Synthetase in the Toxic Cyanobacterium Nostoc sp. Strain 152

Cyanobacteria are a rich source of natural products with interesting pharmaceutical properties. Here, we report the identification, sequencing, annotation, and biochemical analysis of the nostophycin (npn) biosynthetic gene cluster. The npn gene cluster spans 45.1 kb and consists of three open readi...

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Bibliografiske detaljer
Main Authors: Fewer, David P., Österholm, Julia, Rouhiainen, Leo, Jokela, Jouni, Wahlsten, Matti, Sivonen, Kaarina
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2011
Fag:
Genetics and Molecular Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3208980/
https://ncbi.nlm.nih.gov/pubmed/21948844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.05993-11
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