Mechlorethamine-Induced DNA-Protein Cross-Linking in Human Fibrosarcoma (HT1080) Cells

Antitumor nitrogen mustards, such as bis(2-chloroethyl)methylamine (mechlorethamine), are useful chemotherapeutic agents with a long history of clinical application. The antitumor effects of nitrogen mustards are attributed to their ability to induce DNA-DNA and DNA-protein cross-links (DPCs) that b...

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Autori principali: Michaelson-Richie, Erin D., Ming, Xun, Codreanu, Simona G., Loeber, Rachel L., Liebler, Daniel C., Campbell, Colin, Tretyakova, Natalia Y.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3208907/
https://ncbi.nlm.nih.gov/pubmed/21486066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/pr200042u
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