Oxidative stress modulates heme synthesis and induces peroxiredoxin-2 as a novel cytoprotective response in β-thalassemic erythropoiesis

BACKGROUND: β-thalassemic syndromes are inherited red cell disorders characterized by severe ineffective erythropoiesis and increased levels of reactive oxygen species whose contribution to β-thalassemic anemia is only partially understood. DESIGN AND METHODS: We studied erythroid precursors from no...

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Detalhes bibliográficos
Main Authors: De Franceschi, Lucia, Bertoldi, Mariarita, De Falco, Luigia, Santos Franco, Sara, Ronzoni, Luisa, Turrini, Franco, Colancecco, Alessandra, Camaschella, Clara, Cappellini, Maria Domenica, Iolascon, Achille
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2011
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3208676/
https://ncbi.nlm.nih.gov/pubmed/21750082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2011.043612
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