p53 Dependent Centrosome Clustering Prevents Multipolar Mitosis in Tetraploid Cells

BACKGROUND: p53 abnormality and aneuploidy often coexist in human tumors, and tetraploidy is considered as an intermediate between normal diploidy and aneuploidy. The purpose of this study was to investigate whether and how p53 influences the transformation from tetraploidy to aneuploidy. PRINCIPAL...

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Autori principali: Yi, Qiyi, Zhao, Xiaoyu, Huang, Yun, Ma, Tieliang, Zhang, Yingyin, Hou, Heli, Cooke, Howard J., Yang, Da-Qing, Wu, Mian, Shi, Qinghua
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2011
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3208627/
https://ncbi.nlm.nih.gov/pubmed/22076149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027304
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