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Programmable Oligomers Targeting 5′-GGGG-3′ in the Minor Groove of DNA and NF-κB Binding Inhibition

A series of hairpin oligomers containing benzimidazole (Bi) and imidazopyridine (Ip) rings were synthesized and screened to target 5′-WGGGGW-3′, a core sequence in the DNA binding site of NF-κB, a prolific transcription factor important in biology and disease. Five Bi and Ip containing oligomers bou...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Chenoweth, David M., Poposki, Julie A., Marques, Michael A., Dervan, Peter B.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2006
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3208330/
https://ncbi.nlm.nih.gov/pubmed/17095230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2006.10.051
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