Activation of autophagy by alpha-herpesviruses in myeloid cells is mediated by cytoplasmic viral DNA through a mechanism dependent on STING

Autophagy has been established as a player in host defense against viruses. The mechanisms by which the host induces autophagy during infection are diverse. In the case of herpes simplex virus type 1 (HSV-1), dsRNA dependent protein kinase (PKR) is essential for induction of autophagy in fibroblasts...

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Autores principales: Rasmussen, Simon B, Horan, Kristy A, Holm, Christian K, Stranks, Amanda J, Mettenleiter, Thomas C, Simon, A Katharina, Jensen, Søren B, Rixon, Frazer J, He, Bin, Paludan, Søren R
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3208073/
https://ncbi.nlm.nih.gov/pubmed/21998456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1100949
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