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Frustration in protein–DNA binding influences conformational switching and target search kinetics
Rapid recognition of DNA target sites involves facilitated diffusion through which alternative sites are searched on genomic DNA. A key mechanism facilitating the localization of the target by a DNA-binding protein (DBP) is one-dimensional diffusion (sliding) in which electrostatic forces attract th...
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| Главные авторы: | , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3207685/ https://ncbi.nlm.nih.gov/pubmed/22003125 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1109594108 |
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