Ischemia-induced calpain activation causes eukaryotic (translation) initiation factor 4G1 (eIF4GI) degradation, protein synthesis inhibition, and neuronal death

Persistent protein synthesis inhibition (PSI) is a robust predictor of eventual neuronal death following cerebral ischemia. We thus tested the hypothesis that persistent PSI inhibition and neuronal death are causally linked. Neuronal viability strongly correlated with both protein synthesis and leve...

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Main Authors: Vosler, Peter S., Gao, Yanqin, Brennan, Christopher S., Yanagiya, Akiko, Gan, Yu, Cao, Guodong, Zhang, Feng, Morley, Simon J., Sonenberg, Nahum, Bennett, Michael V. L., Chen, Jun
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3207659/
https://ncbi.nlm.nih.gov/pubmed/22006312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1112635108
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