Human Rhinovirus 2A Proteinase Cleavage Sites in Eukaryotic Initiation Factors (eIF) 4GI and eIF4GII Are Different

Several picornaviruses shut down host cellular protein synthesis by proteolytic cleavage of the eukaryotic initiation factor (eIF) 4GI and eIF4GII isoforms. Viral RNA translation is maintained by a cap-independent mechanism. Here, we identify the human rhinovirus 2 2A(pro) cleavage site in eIF4GII i...

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Autores principales: Gradi, Alessandra, Svitkin, Yuri V., Sommergruber, Wolfgang, Imataka, Hiroaki, Morino, Shigenobu, Skern, Tim, Sonenberg, Nahum
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2003
Materias:
Virus-Cell Interactions
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC152112/
https://ncbi.nlm.nih.gov/pubmed/12663812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.8.5026-5029.2003
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