Phosphorylation of the voltage-gated potassium channel Kv2.1 by AMP-activated protein kinase regulates membrane excitability

Firing of action potentials in excitable cells accelerates ATP turnover. The voltage-gated potassium channel Kv2.1 regulates action potential frequency in central neurons, whereas the ubiquitous cellular energy sensor AMP-activated protein kinase (AMPK) is activated by ATP depletion and protects cel...

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Autori principali: Ikematsu, Naoko, Dallas, Mark L., Ross, Fiona A., Lewis, Ryan W., Rafferty, J. Nicole, David, Jonathan A., Suman, Rakesh, Peers, Chris, Hardie, D. Grahame, Evans, A. Mark
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2011
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3207650/
https://ncbi.nlm.nih.gov/pubmed/22006306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1106201108
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