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Intestinal deletion of Pofut1 in the mouse inactivates Notch signaling and causes entero-colitis
BACKGROUND & AIMS: Notch downstream targets are fundamental to intestinal cell lineage commitment and are suggested as therapeutic targets for colon cancer cells. However, the role of endogenous Notch signaling through receptor-ligand interaction, and effects of its longer-term down-regulation o...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3207497/ https://ncbi.nlm.nih.gov/pubmed/18621050 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2008.05.050 |
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