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Amyloid-β-induced Synapse Damage Is Mediated via Cross-linkage of Cellular Prion Proteins
The cellular prion protein (PrP(C)), which is highly expressed at synapses, was identified as a receptor for the amyloid-β (Aβ) oligomers that are associated with dementia in Alzheimer disease. Here, we report that Aβ oligomers secreted by 7PA2 cells caused synapse damage in cultured neurons via a P...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3207431/ https://ncbi.nlm.nih.gov/pubmed/21900234 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.248724 |
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