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α-synuclein induced synapse damage is enhanced by amyloid-β(1-42)

BACKGROUND: The pathogenesis of Parkinson's disease (PD) and dementia with Lewy bodies (DLB) is associated with the accumulation of aggregated forms of the α-synuclein (αSN) protein. An early event in the neuropathology of PD and DLB is the loss of synapses and a corresponding reduction in the...

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Detalhes bibliográficos
Main Authors: Bate, Clive, Gentleman, Steve, Williams, Alun
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3017026/
https://ncbi.nlm.nih.gov/pubmed/21138585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-5-55
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