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β-AR Blockers Suppresses ER Stress in Cardiac Hypertrophy and Heart Failure
BACKGROUND: Long-term β-adrenergic receptor (β-AR) blockade reduces mortality in patients with heart failure. Chronic sympathetic hyperactivity in heart failure causes sustained β-AR activation, and this can deplete Ca(2+) in endoplasmic reticulum (ER) leading to ER stress and subsequent apoptosis....
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3206949/ https://ncbi.nlm.nih.gov/pubmed/22073308 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027294 |
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