β-AR Blockers Suppresses ER Stress in Cardiac Hypertrophy and Heart Failure

BACKGROUND: Long-term β-adrenergic receptor (β-AR) blockade reduces mortality in patients with heart failure. Chronic sympathetic hyperactivity in heart failure causes sustained β-AR activation, and this can deplete Ca(2+) in endoplasmic reticulum (ER) leading to ER stress and subsequent apoptosis....

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Main Authors: Ni, Li, Zhou, Changqing, Duan, Quanlu, Lv, Jiagao, Fu, Xiangning, Xia, Yong, Wang, Dao Wen
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2011
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3206949/
https://ncbi.nlm.nih.gov/pubmed/22073308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027294
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