Inhibition of Striatal Soluble Guanylyl Cyclase-cGMP Signaling Reverses Basal Ganglia Dysfunction and Akinesia in Experimental Parkinsonism

OBJECTIVE: There is clearly a necessity to identify novel non-dopaminergic mechanisms as new therapeutic targets for Parkinson's disease (PD). Among these, the soluble guanylyl cyclase (sGC)-cGMP signaling cascade is emerging as a promising candidate for second messenger-based therapies for the...

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Hauptverfasser: Tseng, Kuei Y., Caballero, Adriana, Dec, Alexander, Cass, Daryn K., Simak, Natalie, Sunu, Elizabeth, Park, Michael J., Blume, Shannon R., Sammut, Stephen, Park, Diana J., West, Anthony R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2011
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3206945/
https://ncbi.nlm.nih.gov/pubmed/22073284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027187
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