Facilitation of Corticostriatal Transmission following Pharmacological Inhibition of Striatal Phosphodiesterase 10A: Role of Nitric Oxide-Soluble Guanylyl Cyclase-cGMP Signaling Pathways

The striatum contains a rich variety of cyclic nucleotide phosphodiesterases (PDEs), which play a critical role in the regulation of cAMP and cGMP signaling. The dual-substrate enzyme PDE10A is the most highly expressed PDE in striatal medium-sized spiny neurons (MSNs) with low micromolar affinity f...

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Publicado no:J Neurosci
Main Authors: Padovan-Neto, Fernando E., Sammut, Stephen, Chakroborty, Shreaya, Dec, Alexander M., Threlfell, Sarah, Campbell, Peter W., Mudrakola, Vishnu, Harms, John F., Schmidt, Christopher J., West, Anthony R.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4388932/
https://ncbi.nlm.nih.gov/pubmed/25855188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1238-14.2015
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