Facilitation of Corticostriatal Transmission following Pharmacological Inhibition of Striatal Phosphodiesterase 10A: Role of Nitric Oxide-Soluble Guanylyl Cyclase-cGMP Signaling Pathways

The striatum contains a rich variety of cyclic nucleotide phosphodiesterases (PDEs), which play a critical role in the regulation of cAMP and cGMP signaling. The dual-substrate enzyme PDE10A is the most highly expressed PDE in striatal medium-sized spiny neurons (MSNs) with low micromolar affinity f...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :J Neurosci
Главные авторы: Padovan-Neto, Fernando E., Sammut, Stephen, Chakroborty, Shreaya, Dec, Alexander M., Threlfell, Sarah, Campbell, Peter W., Mudrakola, Vishnu, Harms, John F., Schmidt, Christopher J., West, Anthony R.
Формат: Artigo
Язык:Inglês
Опубликовано: Society for Neuroscience 2015
Предметы:
Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4388932/
https://ncbi.nlm.nih.gov/pubmed/25855188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1238-14.2015
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы