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Deletion of cannabinoid receptors 1 and 2 exacerbates APC function to increase inflammation and cellular immunity during influenza infection

We and others have reported that simultaneous targeted deletion of CB(1) and CB(2) resulted in exacerbation of immune reactivity, suggesting a role of endocannabinoids in down-regulating immune function. In this study, we demonstrate that APC function is enhanced specifically in the absence of CB(1)...

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Detalhes bibliográficos
Main Authors: Karmaus, Peer W. F., Chen, Weimin, Crawford, Robert B., Harkema, Jack R., Kaplan, Barbara L. F., Kaminski, Norbert E.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Leukocyte Biology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3206470/
https://ncbi.nlm.nih.gov/pubmed/21873455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0511219
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