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Thiourea-Catalyzed Enantioselective Iso-Pictet–Spengler Reactions

[Image: see text] A one-pot condensation of isotryptamines and aldehydes that affords enantiomerically enriched 4-substituted tetrahydro-γ-carbolines is reported. The reaction is induced by a chiral thiourea/benzoic acid dual catalyst system. Purification of the N-Boc-protected products by triturati...

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Autors principals: Lee, Yunmi, Klausen, Rebekka S., Jacobsen, Eric N.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3206290/
https://ncbi.nlm.nih.gov/pubmed/21919478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol202300t
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