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Weak Brønsted Acid–Thiourea Co-Catalysis: Enantioselective, Catalytic Protio-Pictet–Spengler Reactions
[Image: see text] The development of one-pot imine formation and asymmetric Pictet–Spengler reactions co-catalyzed by a chiral thiourea and benzoic acid is described. Optically active tetrahydro-β-carbolines, ubiquitous structural motifs in biologically active natural products, are obtained in high...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2009
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2664157/ https://ncbi.nlm.nih.gov/pubmed/19178157 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol802887h |
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